Exposure into the glucuronide metabolite is 35 to 40 instances better than publicity to the father or mother drug. In vitro data suggest that hydromorphone in clinically relevant concentrations has minimal prospective to inhibit the activity of human hepatic CYP450 enzymes such as CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.Regularly Consider individuals